Any experienced rat or mouse vet will give you the same advice: do not house rats and mice together. They are different species with different behaviours, and they are not natural companions. Keeping them in the same enclosure often leads to stress, fighting, serious injury, or worse. For their safety and wellbeing, they should always be housed separately.
Rats and mice are generally straightforward pets to care for. They require relatively little space, enjoy social interaction with their own species, and are highly intelligent. With appropriate nutrition, enrichment and routine veterinary care, both can live happy, healthy lives.
One aspect of rodent care that should never be overlooked is enclosure security. Rats and mice are exceptional escape artists. A mouse can squeeze through a gap as small as 6mm, and a rat can fit through openings of around 12mm. Their enclosure must be well-constructed, secure and appropriately sized to prevent escapes and injuries. A properly designed habitat is one of the most important foundations of good rat and mouse care.