Distemper is an airborne virus that is extremely contagious. It can be spread through direct or indirect contact, and you can bring it into your home on your shoes and clothing. Ferrets are extremely susceptible to the canine distemper virus, and the fatality rate of ferrets that contract canine distemper is very high. Because this disease is so fatal for ferrets, it is very important that all ferrets are vaccinated. Ferrets can have their first vaccine when they around 8—10 weeks old and then a booster is done 4 weeks later. The vaccine is then done annually to boost their immune system to ensure protection against this virus.